Beilstein J. Org. Chem.2019,15, 1448–1459, doi:10.3762/bjoc.15.145
have different complexation properties to those of their classically prepared analogues.
Keywords: crosslinked cyclodextrin polymers; (2-hydroxy)propylcyclodextrin; mechanochemistry; nucleophile reaction; planetary ball mill; solventlesssynthesis; Introduction
The derivatisation of natural
Beilstein J. Org. Chem.2017,13, 1950–1956, doi:10.3762/bjoc.13.189
small range of compounds.
Conclusion
In summary, we have developed a one-pot, two-step mechanochemical synthesis of fluorinated pyrazolones. The experiments provide a logical approach to multistep solventlesssynthesis under milling conditions and more broadly will assist in the conversion of other
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Graphical Abstract
Scheme 1:
Factors to be considered regarding the physical form in the one-pot two-step mechanochemical proced...